{"id":501,"date":"2020-03-16T22:33:40","date_gmt":"2020-03-16T22:33:40","guid":{"rendered":"http:\/\/testingdomian.com\/gyn-onc\/?page_id=501"},"modified":"2026-03-19T15:35:48","modified_gmt":"2026-03-19T15:35:48","slug":"uterine-cancer","status":"publish","type":"page","link":"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/uterine-cancer\/","title":{"rendered":"Endometrial Cancer"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"501\" class=\"elementor elementor-501\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cbb7148 e-flex e-con-boxed e-con e-parent\" data-id=\"cbb7148\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-724c55c6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"724c55c6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-6770c4f2 elementor-hidden-mobile\" data-id=\"6770c4f2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d054c8d elementor-widget elementor-widget-shortcode\" data-id=\"d054c8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:50,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;],&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\t\t<div data-elementor-type=\"section\" data-elementor-id=\"524\" class=\"elementor elementor-524\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0519c31 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0519c31\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5f4b0d1\" data-id=\"5f4b0d1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f91f80 elementor-widget elementor-widget-heading\" data-id=\"5f91f80\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Cancer Type<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c4abcb7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c4abcb7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a0eaec8\" data-id=\"a0eaec8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0bd1ecd elementor-align-center elementor-widget elementor-widget-button\" data-id=\"0bd1ecd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/ovarian-cancer\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Ovarian Cancer<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e4669a9 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"e4669a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/uterine-cancer\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Endometrial Cancer<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf438c4 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"cf438c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/cervical-cancer\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Cervical Cancer<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd7a2fc elementor-align-center elementor-widget elementor-widget-button\" data-id=\"cd7a2fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/vulvar-cancer\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Vulvar\/Vaginal Cancer<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ca6eeb elementor-align-center elementor-widget elementor-widget-button\" data-id=\"5ca6eeb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/gestational-trophoblastic-neoplasia\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Gestational Trophoblastic Neoplasia<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f56396c elementor-align-center elementor-widget elementor-widget-button\" data-id=\"f56396c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/uterine-sarcoma\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Uterine Sarcoma<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-4b32ccee\" data-id=\"4b32ccee\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-273146e3 elementor-widget elementor-widget-heading\" data-id=\"273146e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Endometrial Cancer<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-637f61bb elementor-widget elementor-widget-text-editor\" data-id=\"637f61bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>About Endometrial Cancer<\/h4><p>Endometrial cancer is the most common gynaecologic cancer and the 4th most common cancer overall in women.\u00a0 It represents 6% of all cancers in Canada. The lifetime risk of a woman developing endometrial cancer is over 3%, or 1 in 39 women in Canada.<\/p><p>Most (95%) cancers of the uterus arise from the lining of the uterus, called the endometrium. These are referred to as endometrial cancers. Rare uterine cancers can also arise from the muscle layer of the uterus (called the myometrium) or the stroma of the endometrium. These are referred to as uterine sarcomas and are discussed separately.<\/p><p>The most important risk factor associated with endometrial cancer is unopposed estrogen which is highly associated with obesity. It can also be associated with use of estrogen supplements, hormone replacement therapy, and occasionally from estrogen producing tumors. The risk of developing endometrial cancer is highest in women over age 50. Certain genetic mutations can increase the risk of developing endometrial cancer. Our team of genetics experts can help patients determine if they have genetic risk factors.<\/p><h4>Types<\/h4><p>There are several types of endometrial cancers, with each having a different clinical behaviour and treatment:<\/p><ul><li>Endometrioid adenocarcinoma<ul><li>This is the most common type of endometrial cancer<\/li><\/ul><\/li><li>Serous adenocarcinoma<\/li><li>Carcinosarcoma<ul><li>Clear cell carcinoma<\/li><li>Undifferentiated\/de-differentiated<\/li><li>Very rare types:<ul><li>Mucinous carcinoma<\/li><li>Mesonephric carcinoma<\/li><li>Neuroiendocrine carcinoma<\/li><\/ul><\/li><\/ul><\/li><\/ul><h4>Molecular Subtypes<\/h4><p>Endometrial cancers are now categorized into four main molecular subgroups:<\/p><ol><li>POLE ultramutated<\/li><li>Mismatch repair deficient (MMRd)<\/li><li>Copy number high\/p53 abnormal<\/li><li>No specific molecular profile (NSMP)<\/li><\/ol><h4>Symptoms<\/h4><p>The majority of women with endometrial cancer will experience abnormal vaginal bleeding. <u>Any vaginal bleeding after menopause needs to be discussed with a doctor<\/u>. Symptoms may include:<\/p><ul><li>Abnormal vaginal bleeding\/abnormal vaginal discharge<\/li><li>Pain or difficulty urinating<\/li><li>Pelvic pain<\/li><li>Change in bowel or bladder function<\/li><li>Unintentional weight loss<\/li><\/ul><h4>Diagnosis<\/h4><p>The diagnosis of endometrial cancer may consist of several investigations:<\/p><ul><li>Complete history &amp; physical exam (including pelvic\/vaginal exam)<\/li><li>Endometrial biopsy (sample of the lining of the uterus)<\/li><li>sometimes a dilatation &amp; curettage (D&amp;C) is required<\/li><li>CT scan of the abdomen, pelvis &amp; thorax<\/li><li>MRI of the pelvis<\/li><\/ul><h4>Treatment<\/h4><p>Management of endometrial cancer is based on the type, grade, stage, and molecular subtype of the cancer. Most women are diagnosed with early-stage endometrial cancer and require surgery. In many cases, our expert surgeons can perform the surgery with state-of-the-art technology using a <a href=\"https:\/\/www.youtube.com\/playlist?list=PLaLgrtXadEF-KMuYCyfsgoZfZTGONILlT\">minimally-invasive<\/a> (laparoscopy or robotic) approach. Our approach identifies and removes only the necessary lymph nodes. Women with advanced stage or grade of cancer may require additional treatment prior to or following surgery, such as <a href=\"https:\/\/www.uhn.ca\/PrincessMargaret\/Clinics\/Chemotherapy_Transfusion\">chemotherapy<\/a> and\/or <a href=\"https:\/\/www.uhn.ca\/PrincessMargaret\/Clinics\/Radiation_Therapy\/Pages\/about_radiation_therapy_centre.aspx?https:\/\/www.uhn.ca\/PrincessMargaret\/Clinics\/Radiation_Therapy\/Pages\/what_expect_radiation_treatment.aspx?utm_source=https:\/\/www.uhn.ca\/princessmargaret\/patientsfamilies\/clinics_tests\/radiation_therapy\/pages\/what_expect_radiation_treatment.aspx&amp;utm_medium=404&amp;utm_campaign=redirects\">radiation<\/a> and\/or <a href=\"https:\/\/www.uhn.ca\/PrincessMargaret\/Clinics\/Chemotherapy_Transfusion\">immunotherapy.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c7e78a1 e-flex e-con-boxed e-con e-parent\" data-id=\"c7e78a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c51e04c elementor-widget elementor-widget-heading\" data-id=\"c51e04c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Five Things to Know About Endometrial Cancer<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45e9eff elementor-widget elementor-widget-image\" data-id=\"45e9eff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-scaled.webp\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"Five Things to Know About Endometrial Cancer\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTUwMSwidXJsIjoiaHR0cHM6XC9cL3Rlc3Rpbmdkb21pYW4uY29tXC9neW5vbmN1aG4tamFuLTI2XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI2XC8wM1wvRW5kb21ldHJpYWxfY2FuY2VyLXNjYWxlZC53ZWJwIn0%3D\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2148\" height=\"2560\" src=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-scaled.webp\" class=\"attachment-full size-full wp-image-5501\" alt=\"Medical infographic-style article page titled \u2018Endometrial cancer\u2019 with five numbered sections explaining risk factors, symptoms, diagnosis, and treatment. A highlighted sidebar lists common risk factors such as advancing age, obesity, polycystic ovary syndrome, unopposed estrogen therapy, and Lynch syndrome. The page also includes references and publication details.\" srcset=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-scaled.webp 2148w, https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-252x300.webp 252w, https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-859x1024.webp 859w, https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-768x915.webp 768w, https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-1289x1536.webp 1289w, https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-1719x2048.webp 1719w, https:\/\/testingdomian.com\/gynoncuhn-jan-26\/wp-content\/uploads\/2026\/03\/Endometrial_cancer-1568x1868.webp 1568w\" sizes=\"(max-width: 2148px) 100vw, 2148px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3811c62 elementor-widget elementor-widget-text-editor\" data-id=\"3811c62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Fertility Preservation<\/h3><p>In some cases, women with endometrial cancer are young and wish to retain the ability to become pregnant in the future. At UHN, we have a devoted clinic to this unique patient population. Our <a href=\"https:\/\/www.womenscollegehospital.ca\/care-programs\/gynecology\/familial-ovarian-cancer-clinic-focc-and-focc-aftercare-clinic\/\"><u>Fertility Preservation in Endometrial Cancer Clinic<\/u><\/a> is tailored to address the specific needs of these women.<br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9c1054 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"e9c1054\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/testingdomian.com\/gynoncuhn-jan-26\/resources\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Additional Patient Resources<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Endometrial Cancer About Endometrial Cancer Endometrial cancer is the most common gynaecologic cancer and the 4th most common cancer overall in women.\u00a0 It represents 6% of all cancers in Canada. The lifetime risk of a woman developing endometrial cancer is over 3%, or 1 in 39 women in Canada. Most (95%) cancers of the uterus [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-501","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Endometrial Cancer\u200b Clinic in Toronto<\/title>\n<meta name=\"description\" content=\"Diagnosed or suspect uterine Cancer (Endometrial Cancer)? 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